Cipla

What is Efudex Cream ?

Efudix cream contains the active ingredient fluorouracil, which is a type of medicine known as a cytotoxic antimetabolite. Fluorouracil is a chemotherapy medicine used to treat cancer. Efudix cream is applied to the skin to treat skin cancer and skin conditions that can develop into cancer (pre-malignant skin lesions).

How to use Efudex Cream:

Use Efudex Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Use a nonmetallic applicator or wear rubber gloves while applying Efudex Cream.
• Gently wash the area where you will apply Efudex Cream. Rinse well, pat dry with a towel, and wait 10 minutes before applying Efudex Cream.
• Wash your hands immediately after applying Efudex Cream, unless they are part of the treated area.
• Do not bandage or cover the treated area, unless directed to do so by your doctor.
• Efudex Cream is for external use only. Do not get it in your eyes, nose, mouth, or genital area. If you get it in your eyes, rinse with a generous amount of cool water right away and contact your doctor.
• If you miss a dose of Efudex Cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Efudex Cream.

Efudex Side Effects:

Important things to remember about Efudex side effects:

1. Most people do not experience all of the Efudex side effects listed.
2. Efudex side effects are often predictable in terms of their onset and duration.
3. Efudex side effects are almost always reversible and will go away after treatment is complete.
4. There are many options to help minimize or prevent Efudex side effects.
5. There is no relationship between the presence or severity of Efudex side effects and the effectiveness of the medication.

The following Efudex side effects are common (occurring in greater than 30%) for patients taking Efudex:

• Pain, itching, burning, irritation, inflammation, dryness, swelling, tenderness at the site of application. This will heal once the treatment is complete.
• These Efudex side effects are less common side effects (occurring in about 10-29%) of patients receiving Efudex:
• Discoloration of the skin or scarring
• Increased sensitivity to sunlight

 Not all side effects are listed above. Some that are rare (occurring in less than 10% of patients) are not listed here.  However, you should always inform your health care provider if you experience any unusual symptoms.

Before you use efudix cream

Do not use Efudix Cream if you:

• are allergic (hypersensitive) to fluorouracil or any other ingredients in this medicine (these are listed in section 6, “Further Information”).
• are pregnant, think you may be pregnant, or are breast-feeding.
• are using any medicines known as antiviral nucleosides (e.g. brivudine, sorivudine). These medicines are usually used to treat chickenpox or shingles.
• Efudix Cream is not for use in anyone under 18 years of age.

 Take special care with Efudix Cream if you:

• are applying this cream around your eyelids, nose or lips, and avoid contact with the eyes or mouth (see section 3, “How to use Efudix Cream”).
• have open cuts. Do not use this cream on open cuts as this can lead to too much cream being absorbed into the blood, which very rarely, can cause side effects.
• have reduced activity/deficiency of the enzyme DPD (dihydropyrimidine dehydrogenase).

Sunlight may increase the effects of Efudix. This may result in increased skin reactions. To prevent this you must try to stay out of direct sunlight as much as possible while using the cream and must not use a sunlamp or sun bed.

• Exposure to UV-radiation (e.g) natural sunlight, tanning salon) should be avoided.

• Closing bandages or dressing may increase inflammatory reactions of the skin.

Using other medicines

Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. This is very important, as using more than one medicine at the same time can strengthen or weaken the effect of the medicines involved.

In particular, tell your doctor if you are using:

• medicines to treat chickenpox or shingles (brivudine, sorivudine) or have used them in the last 4 weeks. These medicines may increase the possibility of unwanted effects with Efudix Cream.
• Pregnancy and breast-feeding

Do not use Efudix Cream and tell your doctor if you are pregnant, think you might be pregnant or you are breast-feeding.

• Driving and using machines
• It is unlikely that the treatment will have any effect on your ability to drive or use machines.
• Important information about some of the ingredients of Efudix Cream

Efudix Cream contains some ingredients that can cause side effects. These are:

    stearyl alcohol and propylene glycol, which can cause local skin irritations (e.g. contact dermatitis, which is an inflammation of the skin).

• E218 (methyl parahydroxybenzoate) and E216 (propyl parahydroxybenzoate), which can cause allergic reactions.
• Do not use Efudix if you are allergic to any of its ingredients.

Warning!

• Take extra care to avoid getting the cream in the eyes, nose or mouth, particularly if you are using the medicine on your face.
• The cream should not be applied to broken skin or open cuts as it may be absorbed into the bloodstream and could cause side effects.
• Sunlight can increase the intensity of the skin reactions to Efudix cream. For this reason you should avoid exposing your skin to direct sunlight as much as possible while using the cream. Do not use sunbeds or sunlamps.

Tibofem (Tibolone 2.5mg Tablets) used for?

Tibofem (Tibolone 2.5mg Tablets) are a hormone replacement therapy (HRT) used to help relieve symptoms of menopause, caused by reduced production of oestrogen after menopause or following surgical removal of the ovaries. These symptoms include, hot flushes, night sweats, sleeplessness, vaginal dryness, headaches, mood swings, lack of concentration and loss of energy. Tibofem (Tibolone 2.5mg Tablets) are also used to help prevent postmenopausal bone loss (osteoporosis) and reduce risk of fracture. Tibofem (Tibolone 2.5mg Tablets) are intended only for post-menopausal women who are over 60 years and who cannot take other HRT medication for the treatment of oestrogen deficiency or other medication for prevention of bone mineral density loss.

Tibofem (Tibolone 2.5mg Tablets) work?

Tibofem (Tibolone 2.5mg Tablets) contain tibolone, a synthetic steroid hormone that is broken down by the body’s metabolism into three compounds that act in a similar way to naturally produced oestrogen, progesterone and testosterone. These metabolites are also tissue-specific which means that they only act on certain tissues. Tibofem (Tibolone 2.5mg Tablets), once metabolised, have oestrogenic effects on bone, vaginal and breast tissue, whereas it has progestogen activity on the endometrium (lining of the uterus) and androgenic effects (like testosterone) in the brain and liver; these actions help restore the hormonal balance to relieve menopausal symptoms like vaginal atrophy, loss of bone density and osteoporosis, as well as other symptoms, such as reducing hot flushes and improved libido. Tibofem (Tibolone 2.5mg Tablets) also have other beneficial effects like lowering cholesterol levels, which tend to increase after menopause.

Side Effects of Tibofem (Tibolone 2.5mg Tablets)?

The most commonly reported side effects when taking Tibofem (Tibolone 2.5mg Tablets) include: lower abdominal pain, abnormal hair growth, vaginal, discharge bleeding or spotting, breast tenderness, haemorrhage, genital itching, vaginal candidiasis (yeast infection), thickened endometrial (lining of the uterus) wall, abnormal growth of the cervix, inflammation of the vagina and vulva (vulvovaginitis).

Tibofem (Tibolone 2.5mg Tablets) contain?

Tibofem (Tibolone 2.5mg Tablets) contain the active ingredient tibolone 2.5 mg, a synthetic steroid hormone that is used for hormone replacement therapy (HRT).

When should Tibofem (Tibolone 2.5mg Tablets) not be used?

You should not use Tibofem (Tibolone 2.5mg Tablets) if you:

• are allergic to tibolone or any ingredients in Tibofem (Tibolone 2.5mg Tablets)
• are pregnant or are breastfeeding
• have a past or family history of carcinoma of the breast, endometrial carcinoma or liver disease
• have a history of thrombosis (blood clots) in the legs( thromboembolism) or lung (pulmonary embolism)
• have a history of heart disease, stroke, severe uncontrolled high blood pressure
• have abnormal vaginal bleeding of unknown cause
• have liver disease or the blood disorder porphyria
• are taking medicines that interact with Tibofem (Tibolone 2.5mg Tablets) including: anticoagulant like warfarin, anticonvulsants like phenytoin and carbamazepin, anti-infectives like rifampicin, rifabutin, the sedative midazolam

Norlut-N ( Norethindrone Acetate 5mg Tablets)

Norlut-N ( Norethindrone Acetate 5mg Tablets) is used as a birth control pill to prevent pregnancy. Norlut-N ( Norethindrone Acetate 5mg Tablets) may also be used to treat endometriosis, a condition where abnormal growth of womb tissue causes painful, heavy or irregular periods. It can also be used to treat other menstrual disorders such as excessive bleeding during periods and premenstrual syndrome (pms). Norlut-N ( Norethindrone Acetate 5mg Tablets) is also used as part of hormone replacement therapy (hrt) in menopausal women and is used to treat breast cancer in certain patients.

Norlut-N ( Norethindrone Acetate 5mg Tablets) Uses

Norlut-N ( Norethindrone Acetate 5mg Tablets) is a man-made form of progesterone, a naturally occurring female sex hormone. It has a number of uses:

• Low-strength progesterone is used in oral contraceptive pill to prevent pregnancy.
• Medium-strength progesterone is used, to treat irregular, painful or heavy periods, to treat endometriosis (where tissue from the lining of the womb is present in places where it is not normally found), to treat premenstrual syndrome (also known as premenstrual tension, PMS or PMT), to delay periods.

High-strength tablets are sometimes used in some female cancers such as breast cancer.

Norlut-N ( Norethindrone Acetate 5mg Tablets) works

Norlut-N ( Norethindrone Acetate 5mg Tablets) works by altering the lining of the uterus. The low-dose contraceptive changes the lining of the womb and so prevents esent in the body) on womb lining, stabilizes this lining and decreases pain and bleeding during the periods or delays the periods. Continuous exposure to Norlut-N ( Norethindrone Acetate 5mg Tablets) decreases the rate of growth of breast cancer cells.

Norlut N Tablet  Side-effects

The following is a list of possible side effects that may occur from all constituting ingredients of Norlut-N ( Norethindrone Acetate 5mg Tablets). This is not a comprehensive list. These side effects are possible, but do not always occur. Some of the side effects may be rare but serious. Consult your doctor if you observe any of the following side effects, especially if they do not go away.

• Bleeding
• Nervousness
• Hair thinning
• Vomiting
• Pain in legs
• Urge to vomit

What is Abamune-L (Abacavir, Lamivudine  600mg 300mg Tablets)?

Abamune-L (Abacavir, Lamivudine  600mg 300mg Tablets) are used to slow down the progression of HIV infection which can lead to AIDS and other related illnesses. Abamune-L (Abacavir, Lamivudine  600mg 300mg Tablets) do not cure AIDS or destroy the HIV virus, but rather delay any further damage to the immune system by stopping production of new viruses.

Abamune-L (Abacavir, Lamivudine  600mg 300mg Tablets) is taken with other antiretroviral medications to treat adults infected with HIV-1. A single pill is the equivalent of 300mg of lamivudine IP and 600mg of abacavir. At least one other anti-HIV medication must be co-administered with Abamune-L (Abacavir, Lamivudine  600mg 300mg Tablets) to effectively prevent HIV from progressing to AIDS.

Used For Abamune-L (Abacavir, Lamivudine  600mg 300mg Tablets)?

Abamune-L (Abacavir, Lamivudine  600mg 300mg Tablets) is a combination of two medications, abacavir and lamivudine which belong to a class of medicines called antiretrovirals. They are used together with other antiretrovirals to slow down the progression of HIV infection (human immunodeficiency virus), which can lead to AIDS (Acquired Immune Deficiency Syndrome) and other related illnesses for example, AIDS – related Complex or ARC.

Dosing & Administration Abamune-L (Abacavir, Lamivudine  600mg 300mg Tablets)

The recommended dose of Abamune-L (Abacavir, Lamivudine  600mg 300mg Tablets) for adults is one pill daily along with other antiretroviral medications. Abamune-L (Abacavir, Lamivudine  600mg 300mg Tablets) may be taken with or without food.

Drug Interactions Abamune-L (Abacavir, Lamivudine  600mg 300mg Tablets)

Ethanol may hinder the kidneys' ability to eliminate abacavir. Zalcitabine cannot be coadministered with Abamune-L (Abacavir, Lamivudine  600mg 300mg Tablets) because zalcitabine and lamivudine inhibit one another.

Work Abamune-L (Abacavir, Lamivudine  600mg 300mg Tablets)?

The two medications abacavir and lamivudine combined together help prevent HIV from reproducing. The HIV virus is responsible for acquired immune deficiency syndrome as HIV infection destroys CD4 (T) cells, which are important to the body’s immune system. The immune system is what helps fight infections. Abamune-L (Abacavir, Lamivudine  600mg 300mg Tablets) do not cure AIDS or destroy the HIV virus, but rather delay further damage to the immune system by stopping production of new viruses. Abamune-L (Abacavir, Lamivudine  600mg 300mg Tablets) do not reduce the risk of passing infection to others. It is important that you continue to take precautions to prevent this from happening as the HIV virus can still be passed on by sexual activity or by contamination with infected blood.

Overdose Warning Abamune-L (Abacavir, Lamivudine  600mg 300mg Tablets)

The effects of an Abamune-L (Abacavir, Lamivudine  600mg 300mg Tablets) overdose are at this point unknown. Do not take more than the recommended dose

Side effects of Abamune-L (Abacavir, Lamivudine  600mg 300mg Tablets)?

Abamune-L (Abacavir, Lamivudine  600mg 300mg Tablets) can cause some side effects. If they do occur and some may be serious, seek medical advice from your health professional as you may require medical attention. As Abamune-L (Abacavir, Lamivudine  600mg 300mg Tablets) contain both abacavir and lamivudine, the side effects reported for each of these have been combined. It has been reported that the most common side effects which could affect at least one to ten in every 100 people include nausea, vomiting, diarrhoea, upper abdominal pain, headache, high temperature, lethargy, fatigue, loss of appetite, hair loss, joint and muscle pain, abacavir hypersensitivity and skin rash. Less common side effects which could affect less than 1 in every 100 people include increased liver enzyme production, anaemia (low red blood cell count), neutropenia (low white blood cell count), reduced number of blood cells important for blood clotting.

You may show symptoms of tiredness or breathlessness if the production of red blood cells is reduced. A reduction in your white blood cell count can make you more susceptible to infection.

Rare side effects which could affect less than one in every 1000 people are breakdown of muscle tissue, increases of an enzyme called amylase and inflammation of the pancreas. Very rare side effects which could affect less than one in every 10,000 people are serious skin reactions and severe anaemia. It has been documented that any changes in fat distribution are associated with antiretroviral medications, which may include loss of fat from legs, arms and face and also increased fat in the abdomen and other internal organs, breasts and the back of the neck. Changes in the amount of fatty substances and glucose in the blood have also been reported. Within the first few weeks of commencing treatment with anti-HIV medicines, some people and in particular those that have been HIV positive for some time, may develop inflammatory reactions for example, pain, redness, swelling and high temperature which may resemble an infection and may be severe. If you notice any changes in your health after commencing HIV treatment or become concerned with any new symptoms, then it is advisable you discuss this with your medical professional immediately. If you experience any of the following, call your doctor immediately. Lactic Acidosis – if you become very sick with accelerated breathing, you may have a condition known as this. High acid levels in the blood can cause rapid breathing and be life threatening. This is more common in women than men. If you experience allergic reactions soon after starting Abamune-L (Abacavir, Lamivudine  600mg 300mg Tablets) medication, for example wheezing, any swelling of the lips/mouth, difficulty in breathing, hay fever, hives or fainting then call your doctor immediately. Like all medications, there may be other side effects that occur in some people that are not listed or some side effects that are not yet known.

What is Adesera (Adefovir Dipivoxil 10mg Tablets)?

Adesera (Adefovir Dipivoxil 10mg Tablets) is an antiviral medicine. It is used to treat long-term hepatitis B virus infection of the liver. Adesera (Adefovir Dipivoxil 10mg Tablets) decreases the amount of virus in your body and therefore reduces further liver damage. However, it may not prevent hepatitis B complications such as liver cancer or end stage liver damage. It also does not prevent the spread of hepatitis B to other people.

Adesera (Adefovir Dipivoxil 10mg Tablets) is an antiviral medication. It works by preventing viral cells from multiplying in the body and infecting new liver cells. Adesera (Adefovir Dipivoxil 10mg Tablets)  is used to treat chronic hepatitis B in adults. This medicine will not cure hepatitis. Adesera (Adefovir Dipivoxil 10mg Tablets)  may also be used for purposes not listed in this medication guide. This medication is used to treat a chronic viral infection of the liver ( hepatitis B ) in people 12 years of age and older. It works by slowing the growth of the virus. It is not a cure for hepatitis B and does not prevent the passing of hepatitis B to others.

Uses Adesera (Adefovir Dipivoxil 10mg Tablets)?

Adesera (Adefovir Dipivoxil 10mg Tablets) is used for treating symptoms of chronic inflammation of the liver (hepatitis) caused by hepatitis B virus (chronic hepatitis B).

Common side effects Adesera (Adefovir Dipivoxil 10mg Tablets)

Weakness, cough, nausea, running nose., vomiting, rash or itching on skin, tiredness, diarrhea, gas, headache

How it works Adesera (Adefovir Dipivoxil 10mg Tablets)?

Adefovir is a nucleotide analogue. It works by slowing the growth of the hepatitis B virus.

What is Dinex EC (Didanosine Delayed - Release 250mg Capsules)?

Dinex EC (Didanosine Delayed - Release 250mg Capsules) is an antiviral medication that prevents human immunodeficiency virus (HIV) cells from multiplying in your body. Dinex EC (Didanosine Delayed - Release 250mg Capsules) is used to treat HIV, which causes the acquired immunodeficiency syndrome (AIDS). Dinex EC (Didanosine Delayed - Release 250mg Capsules) is not a cure for HIV or AIDS. Dinex EC (Didanosine Delayed - Release 250mg Capsules) may also be used for purposes not listed in Dinex EC (Didanosine Delayed - Release 250mg Capsules) guide. Overdose symptoms may include some of the serious side effects listed in Dinex EC (Didanosine Delayed - Release 250mg Capsules) guide.

Pancreatitis

Fatal and non-fatal pancreatitis has occurred during therapy with did anosine used alone or in combination regimens in both treatment-naïve and treatment-experienced patients, regardless of degree of immunosuppression.  Dinex EC (Didanosine Delayed - Release 250mg Capsules)should be suspended in patients with signs or symptoms of pancreatitis. Patients treated with Dinex EC (Didanosine Delayed - Release 250mg Capsules) in combination with stavudine, with or without hydroxyurea, may be at increased risk for pancreatitits.

When treatment with life-sustaining drugs known to cause pancreatic toxicity is required, suspension of didanosine therapy is recommended. In patients with risk factors for pancreatitis, Dinex EC (Didanosine Delayed - Release 250mg Capsules) should be used with extreme caution and only if clearly indicated.  Patients with advanced hiv-1 infection, especially the elderly, are at increased risk of pancreatitis and should be followed closely. Patients with renal impairment may be at greater risk for pancreatitis if treated without dose adjustment.the frequency of pancreatitis is dose-related.

Lactic acidosis/Severe Hepatomegaly with Steatosis

Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues alone or in combination, including didanosine and other antiretrovirals. A majority of these have been in women. Obesity and prolonged nucleoside exposure may be risk factors. Fatal lactic acidosis has been reported in pregnant women who received the combination of didanosine and stavudine with other antiretroviral agents. The combination of didanosine and stavudine should be used with caution during pregnancy and is recommended only if the potential benefit clearly outweighs the potential risk (see warnings and precautions, pregnancy).particular caution should be exercised when administering didanosine to any patient with known risk factors for liver disease; however, cases have also been reported in patients with no known risk factors. Treatment with Dinex EC (Didanosine Delayed - Release 250mg Capsules) should be suspended in any patient who develops clinical signs or symptoms with or without laboratory findings consistent with symptomatic hyperlactatemia, lactic acidosis, or pronounced hepatoxicity (which may include hepatomegaly and steatosis even in the absence of marked transaminase elevations).

Hepatic Toxicity

The safety and efficacy of Dinex EC (Didanosine Delayed - Release 250mg Capsules) have not been established in hiv-infected patients with significant underlying liver disease. During combination antiretroviral therapy, patients with pre-existing liver dysfunction, including chronic active hepatitis, have an increased frequency of liver function abnormalities, including severe and potentially fatal hepatic adverse events, and should be monitored according to standard practice. If there is evidence of worsening liver disease in such patients, interruption or discontinuation of treatment must be considered.

Hepatotoxicity and hepatic failure resulting in death were reported during postmarketing surveillance in hiv-infected patients treated with hydroxyurea and other antiretroviral agents.  Fatal hepatic events were reported most often in patients treated with the combination of hydroxyurea, didanosine and stavudine. This combination should be avoided.

Non-cirrhotic Portal Hypertension

Postmarketing cases of non-cirrhotic portal hypertension have been reported, including cases leading to liver transplantation or death. Cases of didanosine-associated non-cirrhotic portal hypertension were confirmed by liver biopsy in patients with no evidence of viral hepatitis.  Onset of signs and symptoms ranged from months to years after start of didanosine therapy. Common presenting features included elevated liver enzymes, esophageal varices, hematemesis, ascites, and splenomegaly.

Patients receiving Dinex EC (Didanosine Delayed - Release 250mg Capsules) should be monitored for early signs of portal hypertension (eg, thrombocytopenia and splenomegaly) during routine medical visits. Appropriate laboratory testing including liver enzymes, serum bilirubin, albumin, complete blood count, and international normalized ratio (inr) and ultrasonography should be considered. Dinex EC (Didanosine Delayed - Release 250mg Capsules)(Didanosine Delayed - Release 250mg Capsules)should be discontinued in patients with evidence of non-cirrhotic portal hypertension.

Immune Reconstitution Syndrome

Immune reconstitution syndrome has been reported in patients treated with combination antiretroviral therapy, including Dinex EC (Didanosine Delayed - Release 250mg Capsules). During the initial phase of combination antiretroviral treatment, patients whose immune system responds may develop an inflammatory response to indolent or residual opportunistic infections (such as mycobacterium avium infection, cytomegalovirus, pneumocystis jirovecii pneumonia , or tuberculosis), which may necessitate further evaluation and treatment.

Autoimmune disorders (such as graves’ disease, polymyositis, and guillain-barré syndrome) have also been reported to occur in the setting of immune reconstitution; however, the time to onset is more variable, and can occur many months after initiation of treatment.

Pregnancy

Pregnancy Category B:

Reproduction studies have been performed in rats and rabbits at doses up to 12 and 14.2 times the estimated human exposure (based upon plasma levels), respectively, and have revealed no evidence of impaired fertility or harm to the fetus due to didanosine. At approximately 12 times the estimated human exposure, didanosine was slightly toxic to female rats and their pups during mid- and late-lactation. These rats showed reduced food intake and body weight gains but the physical and functional development of the offspring was not impaired and there were no major changes in the f2 generation. A study in rats showed that didanosine and/or its metabolites are transferred to the fetus through the placenta. Animal reproduction studies are not always predictive of human response.

There are no adequate and well-controlled studies of didanosine in pregnant women. Didanosine should be used during pregnancy only if the potential benefit justifies the potential risk.

Fatal lactic acidosis has been reported in pregnant women who received the combination of didanosine and stavudine with other antiretroviral agents. It is unclear if pregnancy augments the risk of lactic acidosis/hepatic steatosis syndrome reported in non-pregnant individuals receiving nucleoside analogs (see warnings and precautions). The combination of didanosine and stavudine should be used with caution during pregnancy and is recommended only if the potential benefit clearly outweighs the potential risk. Healthcare providers caring for hiv-infected pregnant women receiving didanosine should be alert for an early diagnosis of lactic acidosis/hepatic steatosis syndrome.

Pediatric Use

Use of didanosine in pediatric patients from 2 weeks of age through adolescence is supported by evidence from adequate and well-controlled studies of didanosine in adult and pediatric patients (seedosage and administration; undesirable effects; pharmacology). Additional pharmacokinetic studies in pediatric patients support the use of didanosinein pediatric patients who weigh at least 20 kg.

Geriatric Use

In an expanded access program using a buffered formulation of didanosine for the treatment of advanced hiv infection, patients aged 65 years and older had a higher frequency of pancreatitis (10%) than younger patients (5%) (see warnings and precautions). Clinical studies of didanosine, including those for Dinex EC (Didanosine Delayed - Release 250mg Capsules), did not include sufficient numbers of subjects aged 65 years and over to determine whether they respond differently than younger subjects. Didanosine is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection. In addition, renal function should be monitored and dosage adjustments should be made accordingly (see dosage and administration).

Overdosage

There is no known antidote for didanosine overdosage.  In phase 1 studies, in which buffered formulations of didanosine were initially administered at doses ten times the currently recommended dose, toxicities included:pancreatitis, peripheral neuropathy, diarrhea, hyperuricemia, and hepatic dysfunction. Didanosine is not dialyzable by peritoneal dialysis, although there is some clearance by hemodialysis

Dinex EC (Didanosine Delayed - Release 250mg Capsules) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Dinex EC (Didanosine Delayed - Release 250mg Capsules) may cause lactic acidosis (a build-up of lactic acid in the body, which can be fatal). Lactic acidosis can start slowly and get worse over time. Get emergency medical help if you have even mild symptoms of lactic acidosis, such as:

• Muscle pain or weakness.
• Numb or cold feeling in your arms and legs.
• Trouble breathing; feeling dizzy, light-headed, tired, or very weak.
• Stomach pain, nausea with vomiting.
• Fast or uneven heart rate.

Stop using Dinex EC (Didanosine Delayed - Release 250mg Capsules) and call your doctor at once if you have any of these other serious side effects:

• Signs of a new infection such as flu symptoms, easy bruising or unusual bleeding, loss of appetite, mouth sores.
• Severe pain in your upper stomach spreading to your back, nausea and vomiting; itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• Swelling around your stomach, feeling of fullness, feeling short of breath, coughing up blood;
• Numbness, tingling, or pain in your hands or feet.
• Pain in one or both eyes, vision problems, seeing flashes of light.
• Pale skin, easy bruising or bleeding, feeling light-headed, rapid heart rate, trouble concentrating.
• Increased sweating, tremors in your hands, anxiety, feeling irritable, sleep problems (insomnia).
• Diarrhea, unexplained weight loss, menstrual changes, impotence, loss of interest in sex.
• Swelling in your neck or throat (enlarged thyroid).
• weakness or prickly feeling in your fingers or toes.
• Problems with walking, breathing, speech, swallowing, or eye movement.
• severe lower back pain, loss of bladder or bowel control.

 Less serious side effects  may include:

• Mild skin rash;
• Diarrhea; headache;
• Changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

Dinex EC (Didanosine Delayed - Release 400mg Capsules) Introduction

Dinex EC (Didanosine Delayed - Release 400mg Capsules) is an oral antiretroviral agent which is active against HIV infection. This drug is a synthetic purine derivative and similar to stavudine and zidovudine which inhibits the reverse transcriptase enzyme. The drug blocks reproduction of the human immunodeficiency virus which affects people causing AIDS. It inhibits replication of HIV by preventing DNA replication. It is used in combination with other antiretroviral drugs in the treatment of HIV infection and AIDS.

Dinex EC (Didanosine Delayed - Release 400mg Capsules) Use

This drug is known to be used as treatment to HIV infection and postexposure prevention following occupational or nonoccupational exposure to HIV with other antiretrovirals.

Dinex EC (Didanosine Delayed - Release 400mg Capsules) Dosage and administration

The recommended total daily dose is based on body weight and administered as one capsule given once a day. The recommended total daily dose of pediatric patients with a weight of less than 20 kg and who can swallow is based on body weight. The initial dose is 250 mg while doctor may also increase the dose up to 400 mg. Doses may be taken in 1 to 2 divided doses. In infants, dose is 50 to 100 mg/m2 twice daily.

Dinex EC (Didanosine Delayed - Release 400mg Capsules) Important Precautions

Give drug on an empty stomach at least 30 minutes before or 2 hours after meals to avoid decreasing the absorption. IF pancreatitis is suspected, stop giving the drug and don't continue until pancreatitis is ruled out. Adequate hydration is required unless instructed to restrict fluid intake. Inform those with preexisting liver dysfunction that hepatoxicity may result due to therapy. Inform physician if you have a kidney disease, since you may need a lower dosage. Take drug at exact prescribed timing since missing doses may increase the chance of virus becoming resistant to HIV medications.

Dinex EC (Didanosine Delayed - Release 400mg Capsules) Side effects

The common side effects of the drug are nausea, vomiting, diarrhea or changes in body fat. Report immediately if there are instances of any loss of sensation, numbness, or tingling in fingers, toes or feet; persistent unresolved abdominal distress, changes in vision, or signs of infection such as burning on urination, perineal itching, and white plaques in mouth, unhealed sores, persistent sore throat and cough. Adverse reactions may also occur such as aggressive reaction, allergic reaction, convulsion, liver failure and neuropathy.

Other important Information on Dinex Ec Capsule

Missing a dose

In case you miss a dose, take it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not take extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.

Overdosage of Dinex EC (Didanosine Delayed - Release 400mg Capsules)

Do not take more than prescribed dose. Taking more medication will not improve your symptoms; rather they may cause poisoning or serious side effects. If you suspect that you or anyone else who may have overdosed of Dinex EC (Didanosine Delayed - Release 400mg Capsules), please go to the emergency department of the closest hospital or nursing home. Bring a medicine box, container, or label with you to help doctors with necessary information.

Do not give your medicines to other people even if you know that they have the same condition or it seems that they may have similar conditions. This may lead to overdosage.

Storage of Dinex EC (Didanosine Delayed - Release 400mg Capsules)

Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.

Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Dinex EC (Didanosine Delayed - Release 400mg Capsules).

Expired Dinex EC (Didanosine Delayed - Release 400mg Capsules)

Taking a single dose of expired Dinex EC (Didanosine Delayed - Release 400mg Capsules) is unlikely to produce an adverse event. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Expired drug may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to take expired drug. If you have a chronic illness that requires taking medicine constantly such as heart condition, seizures, and life-threatening allergies, you are much safer keeping in touch with your primary health care provider so that you can have a fresh supply of unexpired medications.

What is Lamivir (Lamivudine 150mg Tablet)?

Lamivir (Lamivudine 150mg Tablet) containing the active ingredient lamivudine is considered a nucleoside reverse transcriptase inhibitor (NRTI) type of medication. The medication can help decrease the amount of the HIV cells from multiplying in the body to allow the immune system to work better. The tablets should be taken with other medication to lower the chance of getting HIV complications such as AIDS, serious infections or cancer. It can be used to help treat HIV but cannot be used to cure the condition.

Lamivir (Lamivudine 150mg Tablet) Uses

Lamivir (Lamivudine 150mg Tablet) is indicated for use in conjunction with other antiretroviral medicines to treat HIV-1 infections. It works by stopping the virus from spreading and destroying CD4 helper cells. This medicine is classified as a nucleoside analog and its mechanism of action involves blocking the action of the viral RT (reverse transcriptase, an enzyme that the virus needs to replicate), and this results in the termination of the viral DNA chain. The HIV virus can develop a resistance to drugs, and a particular type of mutation of which occurs in the reverse transcriptase gene (called the M184V mutation) may occur if this medicine is used on its own. Resistance can reduce the effectiveness of the medicine, and to combat this, your physician will also advice concomitant treatment with other medicines to ensure that the infection is kept under control.

How does Lamivir (Lamivudine 150mg Tablet) work?

Lamivir (Lamivudine 150mg Tablet) contain lamivudine, which is a nucleoside analogue reverse transcriptase inhibitor (NRTI) that is only effective against retroviruses (RNA virus) like HIV. Lamivudine in Lamivir (Lamivudine 150mg Tablet) 150mg works by inhibiting the action of the viral-specific enzyme reverse transcriptase (RT), which is needed for the virus to be able to replicate. Retroviruses convert RNA to DNA, which is then integrated into the DNA of infected immune cells so that the virus can replicate. A nucleoside is a building block of DNA that is needed by the virus to replicate, and nucleoside analogues, like lamivudine (analogue of cytidine) in Lamivir (Lamivudine 150mg Tablet), become incorporated into the DNA that is copied from the viral RNA by an enzyme called reverse transcriptase. This blocks the action of reverse transcriptase and terminates the viral DNA chain so that it cannot become integrated into the DNA of the infected immune cell, which means that no more HIV can be produced. Lamivudine in Lamivir (Lamivudine 150mg Tablet) has been shown to act additively or synergistically with other anti-HIV agents particularly zidovudine, which means that that it increases the effectiveness of the other drug. Lamivir (Lamivudine 150mg Tablet) helps slow down the replication of HIV within your body but does not kill the virus already incorporated in the CD4+ cells or prevent the spread of the infection to others.

Lamivir (Lamivudine 150mg Tablet) Dosage and Administration

Lamivir (Lamivudine 150mg Tablet) are provided as a 150mg strength formula, and dosage is by means of oral administration. Patients may take it without regard to meals, however those who find it difficult to swallow the tablet should contact their physician for advice. It is essential that no doses are missed, as doing so could increase the likelihood of developing viral resistance. Your physician will calculate the right dosage for you. In most cases, adults treating an infection caused by HIV will be told to administer 150mg (one tablet) twice per day, and your physician will also decide for you (based on your unique circumstances) what other antiretroviral medicines you need to take. Strict compliance with the physician`s instructions is required at all times.

Lamivir (Lamivudine 150mg Tablet) Side effects

Patients who take Lamivir (Lamivudine 150mg Tablet) might suffer from side effects, such as:

• Insomnia
• Dyspepsia
• Blocked nose
• Concentration problems
• Cramps which affect the abdomen

It is vital that a physician is kept informed of all side effects which occur throughout the course of treatment. The occurrence of serious and harmful reactions is generally considered to be less common, however all patients are advised to be aware of this risk. Visit your physician or attend the emergency room straight away should you suffer from fever, discolored urine, weakness or any other severe side effects that have not been referenced here.

Lamivir (Lamivudine 150mg Tablet) Warnings

Immediately proceed to your nearest emergency department if you suffer an allergic reaction. Symptoms usually associated with such a reaction include difficulty breathing or swallowing, chest tightness, swelling, skin rashes, and hives.

Lamivir (Lamivudine 150mg Tablet) is not always suitable for all patients. Always consult your health care provider prior to using this medication if you are pregnant, breastfeeding, trying to conceive, using any other medication (prescription or non-prescription), using any herbal products or supplements, or if you have any allergies or other health problems.

The correct dosage and prescription commonly depend on the patient and the condition being treated. Do not adjust your dosage without the approval of your health care provider. This product is only for use as prescribed and instructed.

When should Lamivir (Lamivudine 150mg Tablet) not be used?

You should not use Lamivir (Lamivudine 150mg Tablet) if you:

• are allergic to lamivudine or any ingredients in Lamivir (Lamivudine 150mg Tablet)
• are taking any other retroviral medication containing lamivudine
• are pregnant or are breastfeeding
• have kidney or liver disease
• are taking medicines that interact with Lamivir (Lamivudine 150mg Tablet), including: the antibiotic trimethoprim, the antriretrovirals zalicitabine

How should Lamivir (Lamivudine 150mg Tablet) be taken?

You should take your Lamivir (Lamivudine 150mg Tablet) with a glass of water, with or without food, once or twice daily. The dose you take depends on your condition and your doctor’s recommendations and should be taken in combination with other HIV medication. You should continue to take your Lamivir (Lamivudine 150mg Tablet) 150mg for as long as recommended by your doctor, and you will be monitored carefully to ensure that you do not develop any serious side effects, in which case your doctor will probably recommend that you stop taking your Lamivir (Lamivudine 150mg Tablet). Do not suddenly stop taking your Lamivir (Lamivudine 150mg Tablet) as this may increase risk of HIV resistance.

Lamivir (Lamivudine 150mg Tablet) Precautions

Lamivir (Lamivudine 150mg Tablet) cannot cure HIV. Therefore, patients are still able to infect others. Precautions such as practicing safe sex can ensure that the risk of infecting others is minimized.

Serious risks associated with this medicine include liver disease (which has the potential to be fatal) and lactic acidosis. Ensure that you discuss the risks of this with your physician prior to commencing treatment.

Stavir (Stavudine 30mg Capsules)

Stavir (Stavudine 30mg Capsules) contains Stavudine as an active medicinal substance. Stavudine is a synthetic nucleoside, analog of deoxythymidine with potent antiretroviral activity. It is used along with other antiretroviral agents to treat human immunodeficiency syndrome or HIV-1 infection. Stavudine is an FDA-approved drug prescribed for the treatment of HIV-1 in infants, children, and adults.

Why is this medication prescribed?

Stavir (Stavudine 30mg Capsules) is used along with other medications to treat human immunodeficiency virus (HIV) infection. Stavir (Stavudine 30mg Capsules) is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It works by decreasing the amount of HIV in the blood. Although Stavir (Stavudine 30mg Capsules) does not cure HIV, it may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer. Taking these medications along with practicing safer sex and making other life-style changes may decrease the risk of transmitting (spreading) the HIV virus to other people.

What is Stavir (Stavudine 30mg Capsules) used for?

Stavir (Stavudine 30mg Capsules) is used to treat Human immunodeficiency syndrome or HIV-1 infection.  HIV is a lentivirus (a subgroup of retrovirus) that causes Acquired Immunodeficiency Syndrome (AIDS).  AIDS is a disease in which progressive failure of the immune system leads to opportunistic infections and cancers to prosper.

How does  Stavir (Stavudine 30mg Capsules)  work?

Stavir (Stavudine 30mg Capsules) works by blocking reverse transcriptase enzyme, preventing HIV-1 infection from multiplying in the body and can reduce the amount of HIV in the body of an infected person.

Missed dose of Stavir (Stavudine 30mg Capsules):

If you have forgotten a dose, take it as soon you remember and go back to your usual dosing schedule. If the time to take the next dose is near, leave the forgotten dose and take the next dose. Do not double up the dose to compensate the missed one.

• Take the capsule for as long as your doctor recommended.

What are Side effects of Stavir (Stavudine 30mg Capsules)?

Like other medicines, Stavir (Stavudine 30mg Capsules) may cause adverse effects. Seek medical attention, in case the following troubles arise:

• Neuropathy
• Vomiting
• Headache
• Diarrhea
• Nausea

Some adverse effects of Stavir (Stavudine 30mg Capsules) can be serious. Visit the doctor immediately, in the following situations.

• Rash
• Difficulty moving your hands and feet
• Burning, tingling, numbness in the hands or feet
• Pain in the hands and feet

When should Stavir (Stavudine 30mg Capsules) not be used?

Tell the doctor before consuming Stavir (Stavudine 30mg Capsules):

• If you are hypersensitive to the medicine, or its components.
• If you are taking alcohol products.
• If you have gallstones.
• If you have ever had problems with your pancreas and kidney diseases.
• If you have or ever had neuropathy.
• The drug may cause dizziness. Do not drive or use machinery, while taking Stavir (Stavudine 30mg Capsules) as these activities may require a high degree of mental attention.
• If you are pregnant or intending to become pregnant. You should discuss the benefits and risks of taking Stavir (Stavudine 30mg Capsules) during pregnancy. Breastfeeding women are advised not to take Stavir (Stavudine 30mg Capsules) as it may pass into breast milk and harm the nursing baby.

Remember the following things, to avoid transmission of HIV infection on to others:

• Avoid sharing needles and other injection equipment with other people.
• Avoid sharing personal things that can have blood fluid on them, like toothbrushes and razors.
• Avoid practicing sex without protection. Do practice safe sex by using polyurethane or latex to decrease the chance of sexual contact with vaginal secretions, semen, and blood.

How should Stavir (Stavudine 30mg Capsules) be taken?

• Stavir (Stavudine 30mg Capsules) comes in the form of a capsule. Swallow the capsule with a glass of water. It may be taken with or without a meal.
• The dosage of the drug is based on the body weight of a patient.
• To treat adults who weigh less than 60 kg: The recommended dose is 30 mg every 12 hours.
• To treat adult patients who weigh at least 60 kg: The recommended dose is 40 mg every 12 hours.
• To treat pediatric patients:

Infants from birth to 13 days old- The recommended dose are 0.5 mg/kg every 12 hours.

An infant who is at least 14 days old and whose weight is less than 30 kg- The recommended dose is 1 mg/kg every 12 hours.

• A paediatric patient whose weight is at least 30 kg: The recommended dosage is adult dosage.
• Take the capsule exactly as prescribed by the doctor. Do not alter the dosage plan.
• Overdose: Seek medical attention immediately, in the case of an overdose of Stavir (Stavudine 30mg Capsules).

Stavir (Stavudine 40mg Capsules)

Stavir (Stavudine 40mg Capsules) is used in combination with other anti-virus medicines for the treatment of human immunodeficiency virus (HIV) infection. HIV is the virus that causes acquired immune deficiency syndrome (AIDS).

Stavir (Stavudine 40mg Capsules) will not cure or prevent HIV infection or AIDS. It helps to keep HIV from reproducing and appears to slow down the destruction of the immune system. This may help delay problems that are usually related to AIDS or HIV disease.Stavir (Stavudine 40mg Capsules) will not keep you or your child from spreading HIV to other people. People who receive this medicine may continue to have the problems usually related to AIDS or HIV disease.

How it works Stavir (Stavudine 40mg Capsules)?

Stavir (Stavudine 40mg Capsules) acts by interfering with the viral reproductive system. It gets incorporated into viral DNA with the help of two enzymes, i.e. HIV reverse transcriptase and HBV polymerase and ultimately stops the formation of DNA. This way, it stops the DNA formation which is very vital for virus survival.  This way, it delays the progression of viral infestation in the  body.

How much to take Stavir (Stavudine 40mg Capsules)?

The dosage is solely decided by the Doctor after assessing your condition and various factors such as age, gender and body weight. One can’t fix the dose as it varies from patient to patient. The usual recommended dose is 30 mg once a day for 12 hours. It can be increased or decreased depending upon the patient’s condition. Always take the dose as prescribed by the Doctor.

When should you avoid it?

You should not take Stavir (Stavudine 40mg Capsules) if you:

• Are allergic to Stavir (Stavudine 40mg Capsules)
• Are prone to allergies
• Are suffering from kidney disease
• are suffering from pancreas problem
• Are suffering from diabetes
• Are overweight
• are pregnant or planning to conceive
• are breast feeding a child

What are the strengths available?

Stavir (Stavudine 40mg Capsules) is available in following strength preparation on our website:

• Stavir 40 mg
• Stavir 30 mg

What are the Stavir (Stavudine 40mg Capsules) side effects?

Every medicine shows some side effects, same way this drug also has some undesired effects with it. Stavudine shows common side effects such as:

• Headache
• Diarrhea
• Nausea
• Vomiting
• Loss of appetite
• Blurred vision
• Constipation

Some serious and rare side effects that need serious consideration are stated below:

• Skin rashes
• Hives
• Chills
• Liver problems
• Numbness, tingling or burning sensation

What if you miss the dose?

Try to take the medicine at the same time each day. This reduces the chances of missing a dose. Talk to your Doctor if you miss the dose. Don’t double up the dose in order to catch up with the previous one.

Are there any possible drug interactions?

Always inform your doctor about the drugs you are taking till date. Give a complete list of prescription or non prescription drugs and any other disease conditions. This way, the doctor is able to decide and give you the list of drugs and other things that may interact with Stavir (Stavudine 40mg Capsules). Few drugs like Didanosine, Zidovudine and hydroxyurea that may interact with Stavir (Stavudine 40mg Capsules).

What are the things to be taken care of?

• Always take the medicine as per the prescription
• Don’t use the expired drugs
• Don’t share your medicine with anybody, even if they have the same symptoms
• Avoid drinking alcohol while you take Stavir (Stavudine 40mg Capsules). Drinking alcohol may increase your risk of liver or pancreas problems.
• Stavir (Stavudine 40mg Capsules) may affect your blood sugar levels, check blood sugar levels closely
• Always store the medicine at the room temperature and away from moisture, heat and light
• This drug can cause severe dizziness so immediate consult with your doctor
• During pregnancy, one can take this medicine only after Doctor’s recommendation in order to prevent the further transmission of the HIV virus to the baby
• Consult with your pharmacist about the proper disposal of the drug
• Keep a complete record of all the medicines you are taking along with this medicine

Viraday Tablets(Tenofovir Disoproxil Fumarate 300mg, Emtricitabine 200mg, Efavirenz 600mg Tablets)

Viraday Tablets (Tenofovir Disoproxil Fumarate 300mg, Emtricitabine 200mg, Efavirenz 600mg Tablets) contains  different anti-retroviral drugs that are effective in treatment of retroviruses (RNA viruses) such as Human Immunodeficiency Virus (HIV).

Viraday Tablets (Tenofovir Disoproxil Fumarate 300mg, Emtricitabine 200mg, Efavirenz 600mg Tablets)Uses

Viraday (Tenofovir Disoproxil Fumarate 300mg, Emtricitabine 200mg, Efavirenz 600mg Tablets) is a combination medicine used to treat HIV (Human Immunodeficiency Virus) in adults. Each tablet contains a combination of three antiretroviral drugs: Tenofovir Disoproxil Fumarate (Viread) 300mg + Emtricitabine (Emtriva) 200mg + Efavirenz (Sustiva) 600mg.

Viraday (Tenofovir Disoproxil Fumarate 300mg, Emtricitabine 200mg, Efavirenz 600mg Tablets) contains three different anti-retroviral drugs that are effective in treatment of retroviruses (RNA viruses) such as Human Immunodeficiency Virus (HIV). Replication of the HIV virus is caused by the action of viral-specific enzyme reverse transcriptase. These drugs inhibit the action of these enzymes.

How  Viraday Tablets (Tenofovir Disoproxil Fumarate 300mg, Emtricitabine 200mg, Efavirenz 600mg Tablets) work?

Viraday (Tenofovir Disoproxil Fumarate 300mg, Emtricitabine 200mg, Efavirenz 600mg Tablets) contain a combination of three antiretroviral drugs, efavirenz, emtricitabine and tenofovir disoproxil fumarate, which are only effective against RNA viruses (retroviruses) like Human Immunodeficiency Virus (HIV). These three drugs each work by inhibiting the action of the viral-specific enzyme reverse transcriptase (RT) which is needed for the virus to be able to replicate. Retroviruses convert RNA to DNA, which is then integrated into the DNA of infected immune cells so that the virus can replicate. Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and acts by binding to a specific site on the RT enzyme and blocks its action in a manner that is noncompetitive with nucleosides, which are the precursors to the building blocks of DNA and RNA. Tenofovir and Emtricitabine are both nucleoside analogue reverse transcriptase inhibitors (NRTI), which means that they block the action of RT by competing with one of the nucleosides needed to transcribe the viral RNA into DNA, becoming incorporated into the chain of newly synthesized viral DNA and preventing it from growing (chain termination). Emtricitabine is an analogue of cytidine and tenofovir is an analogue of adenosine. The combined action of the three antiiretroviral drugs in Viraday (Tenofovir Disoproxil Fumarate 300mg, Emtricitabine 200mg, Efavirenz 600mg Tablets) prevents the integration of the virus into the DNA of the infected CD4+ immune cell, which inhibits the replication of HIV so that no more virus can be produced and this reduces the viral load (amount of virus). Viraday (Tenofovir Disoproxil Fumarate 300mg, Emtricitabine 200mg, Efavirenz 600mg Tablets) slow down the replication of HIV within your body but does not kill the virus already incorporated in the CD4+ cells or prevent the spread of the infection to others.

What do I do if I miss a Viraday Tablets dose

Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Do not change the dose or stop this drug. Talk with the doctor.

Viraday Tablets (Tenofovir Disoproxil Fumarate 300mg, Emtricitabine 200mg, Efavirenz 600mg Tablets) Side effects

Viraday (Tenofovir Disoproxil Fumarate 300mg, Emtricitabine 200mg, Efavirenz 600mg Tablets) can result in some unwanted side effects, especially at the beginning of treatment. Many side effects will be minor and temporary. The most common side effects of Viraday (Tenofovir Disoproxil Fumarate 300mg, Emtricitabine 200mg, Efavirenz 600mg Tablets) are:

• Headaches
• Gastrointestinal conditions (nausea, diarrhea, constipation, stomach pain)
• Loss of appetite or eating disorders
• Dizziness and/or fatigue
• Rashes, hot flushes or other skin conditions
• Mood changes, depression, anxiety
• Nightmares, trouble sleeping, insomnia

A very rare, but potentially fatal adverse effect of Viraday (Tenofovir Disoproxil Fumarate 300mg, Emtricitabine 200mg, Efavirenz 600mg Tablets) is lactic acidosis, a build up of lactic acid in the blood due to liver damage, liver enlargement or fatty deposits in the liver. This can lead to liver failure, kidney failure or pancreatits, and even fatality if left untreated.

When should Viraday Tablets (Tenofovir Disoproxil Fumarate 300mg, Emtricitabine 200mg, Efavirenz 600mg Tablets) not be used?

You should not use Viraday (Tenofovir Disoproxil Fumarate 300mg, Emtricitabine 200mg, Efavirenz 600mg Tablets) tablets if you:

• are allergic to efavirenz, emtricitabine and tenofovir or any ingredients in Viraday (Tenofovir Disoproxil Fumarate 300mg, Emtricitabine 200mg, Efavirenz 600mg Tablets)
• are pregnant or are breastfeeding
• have kidney or liver disease
• have hepatitis B infection
• have a mental illness, including depression; convulsions; or bone disease like osteoporosis without discussion with your doctor, as your condition may worsen
• are taking medicines that interact with Viraday (Tenofovir Disoproxil Fumarate 300mg, Emtricitabine 200mg, Efavirenz 600mg Tablets), including: cisapride for reflux, midazolam and triazolam for sedation and anxiety, the antipsychotic pimozide, bepridil for angina, Cafergot for migraine, the antifungal voriconazole and Itraconazole, other medications containingf efavirenz, emtricitabine, or tenofovir, other retrovirals like ritonavir or lamivudine, herbal preparations containing St. John's wort, the anticonvulsant phenobarbital, antibiotics like clarithromycin rifampicin, statins like simvastatin for lowering cholesterol, the anticoagulant warfarin, the anticonvulsants carbamazepine and Phenytoin, the antidepressant sertraline, the calcium channel blocker diltiazem for high blood pressure, oral contraceptives

Viraday Tablets (Tenofovir Disoproxil Fumarate 300mg, Emtricitabine 200mg, Efavirenz 600mg Tablets) Precautions

Viraday (Tenofovir Disoproxil Fumarate 300mg, Emtricitabine 200mg, Efavirenz 600mg Tablets) is not suitable for everybody. You should discuss with your doctor any of the following:

• if  allergic to tenofovir, emtricitabine or efavirenz
• if you have had reactions to any other medicines
• if you are pregnant, trying to become pregnant, or breastfeeding
• if you suffer from kidney or liver disease
• if you have any infections, especially hepatitis B
• if you have any form of mental illness including depression
• if you have any bone disease including osteoporosis
• if you are taking any other medicines including prescription drugs, non-prescription drugs, nutritional supplements or herbal treatments

Trioday (Tenofovir Disoproxil Fumarate 300mg, Lamivudine 300mg, Efavirenz 600mg Tablets)

Trioday (Tenofovir Disoproxil Fumarate 300mg, Lamivudine 300mg, Efavirenz 600mg Tablets) are indicated for the treatment of hiv-1 infection in adults. It is recommended that Trioday (Tenofovir Disoproxil Fumarate 300mg, Lamivudine 300mg, Efavirenz 600mg Tablets) be taken on an empty stomach, preferably at bedtime. Bedtime dosing may improve the tolerability of nervous system symptoms associated with efavirenz. The increased efavirenz concentrations observed following administration of efavirenz with food may lead to an increase in the frequency of adverse events. Trioday (Tenofovir Disoproxil Fumarate 300mg, Lamivudine 300mg, Efavirenz 600mg Tablets) are not indicated for use in pediatric patients.

Trioday (Tenofovir Disoproxil Fumarate 300mg, Lamivudine 300mg, Efavirenz 600mg Tablets) is a combination of tenofovir, lamivudine, and efavirenz to treat hiv infected people. Each film-coated tablet contains 600 mg of efavirenz, 300 mg of lamivudine and another 300 mg of tenofovir disoproxil fumarate. It can be taken alone and with combination of other medications. This medication helps to control the hiv infection and help to improve the quality of life. In additions, it lowers the risk to get hiv complications like new infections, cancer. It does not cure the infection perfectly, but somehow prevent the spread to others through sexual contact or blood contamination, including sharing the needles.

Trioday (Tenofovir Disoproxil Fumarate 300mg, Lamivudine 300mg, Efavirenz 600mg Tablets) Uses

Lamivudine indicated as part of antiretroviral combination therapy for the treatment of Human Immunodeficiency Virus (HIV) infected adults and children and also used in the treatment of Hepatitis B virus infection.

How it Trioday (Tenofovir Disoproxil Fumarate 300mg, Lamivudine 300mg, Efavirenz 600mg Tablets) works

Lamivudine belongs to a class of medication called nucleoside reverse transcriptase inhibitors. It decreases the amount of virus (HIV and hepatitis) in the blood. It also increases the number of infection fighting cells in the body (CD4 cells). It does not cure HIV completely but reduces the chances of getting acquired immunodeficiency syndrome (AIDS) and HIV related infections or cancer.

Trioday (Tenofovir Disoproxil Fumarate 300mg, Lamivudine 300mg, Efavirenz 600mg Tablets) Contraindications:

Trioday (Tenofovir Disoproxil Fumarate 300mg, Lamivudine 300mg, Efavirenz 600mg Tablets) is contraindicated in patients with hypersensitive to any of the components of the product. It should not be administered concurrently with astemizole, bepridil, cisapride, midazolam, pimozide, and triazolam or ergot derivatives. It is because for cyp3a4 as efavirenz could result in the inhibition of the metabolism of this medication and can create a serious life threatening adverse events, including cardiac arrhythmias, prolonged sedation, or respiratory depression. Again it should not be administered concurrently with voriconazole as it is significantly decreased voriconazole plasma concentrations.

This medication is dangerously contraindicated with amprenavir, fosamprenavir, calcium, atazanavir, indinavir, lopinavir, ritonavir, saquinavir, warfarin, carbamazepine, phenytoin, phenobarbital, setailine, itraconazole, ketoconazole, clarithromycin, rifampin, rifabutin, avorvastin, paravastin, simvastatin, methadone, ethinyl estradiol, ditiazem.

It is better to tell your doctor before medication and be frank if you take any other medication, including all the prescription and non-prescription medications, also if you take vitamins and other herbal products.

Trioday (Tenofovir Disoproxil Fumarate 300mg, Lamivudine 300mg, Efavirenz 600mg Tablets) Dosage and Administrations:

One tablet once a day is the recommended dosage of Trioday (Tenofovir Disoproxil Fumarate 300mg, Lamivudine 300mg, Efavirenz 600mg Tablets) medicine. It can be taken on an empty stomach for the best result most preferably at bedtime because during this time it may improve the tolerability of nervous system symptoms associated with efavirenz. Administration of this medicine with a high-fat meal increased the mean AUC and Cmax of efavirenz by 28% and 79% respectively, and in combination of Tenofovir and lamivudine with a high-fat meal or a light meal increased the mean AUC and Cmax of Tenofovir by 35% and 15% respectively and it does not affect Lamivudine exposures.

Zidovir (Zidovudine 300mg Tablets)

Zidovir (Zidovudine 300mg Tablets), also sold under the brands Retrovir and Zidovir among several other trade names, is an antiviral drug. This medication belongs to a group of HIV medicines called reverse transcriptase inhibitors that prevent the HIV virus from reproducing in the body.

Zidovir (Zidovudine 300mg Tablets) is prescribed for the treatment of HIV that causes the disease called acquired immunodeficiency syndrome or AIDS. However, this medication will not cure the body of HIV or AIDS. This medication may also be given for conditions not mentioned here.

Important Information about Zidovir (Zidovudine 300mg Tablets)

Do not take Zidovir (Zidovudine 300mg Tablets) antiviral HIV medicine (Retrovir, Zidovir) if you have a known allergy to it or any medicine that has Zidovir (Zidovudine 300mg Tablets). Also do not take Zidovir (Zidovudine 300mg Tablets) with other medicines that also contain Zidovir (Zidovudine 300mg Tablets) or Stavudine.

Lactic acidosis has been observed in some people who took Zidovir (Zidovudine 300mg Tablets). Initial symptoms of lactic acidosis may deteriorate over time and can prove fatal. Hence you must get medical attention right away on first signs of lactic acidosis such as muscle pain or weakness, numb or cold feeling in the limbs, breathing trouble, stomach pain, or nausea with vomiting.

Zidovir (Zidovudine 300mg Tablets) can also cause severe and life threatening damage to your liver. Let your doctor know in advance if you have a condition affecting liver, especially Hepatitis C. Seek medical attention right away if you have any of the following symptoms of liver damage: sever pain in upper stomach which advances to the back, nausea and vomiting, fast heartbeats, itching, loss of appetite, dark urine, clay colored stools, or jaundice.

Zidovir (Zidovudine 300mg Tablets) can lower the count of white blood cells, the component of blood that helps the body to fight infections. You must take necessary precautions to avoid getting infected such as not being near sick people or avoiding activities that increases the risk of bleeding. Let your doctor know right away if you get any signs of an infection while taking this medication.

Lamivudine is an FDA pregnancy category C drug. It is not known if it can harm an unborn baby if taken while being pregnant. HIV can be transmitted to your baby if you are not treated properly during pregnancy.

Zidovir (Zidovudine 300mg Tablets) Uses

Zidovir (Zidovudine 300mg Tablets) is classified as a nucleoside analog, and it treats HIV infections by inhibiting viral reverse transcriptase and DNA polymerases. The HIV virus needs to replicate its DNA in order to spread and infect more cells. An enzyme called RT (reverse transcriptase) is needed for this to take place, and by blocking RT, this medicine helps to terminate the DNA chain and prevent the virus from multiplying. Improvements in the clinical condition of patients can thereby be achieved. Some researchers have studied it for HIV prevention (prophylaxis).

How should I take Zidovir (Zidovudine 300mg Tablets)?

Take Zidovir (Zidovudine 300mg Tablets) HIV/AIDS medication (Retrovir, Zidovir) strictly according to your doctor’s direction or according to the instructions on the medication label. Do not alter the dosage unless your doctor advises you to do so. Also, do not take this medication after the prescribed period is over. All medications come with a patient leaflet. Refer the instructions in them for detailed information on that particular medication.

HIV/AIDS is usually treated with a combination of drugs. Always take the prescribed drugs as directed by your doctor. Store this medication in a cool and dry place. Always store Zidovir (Zidovudine 300mg Tablets) in a cool and dry place.

Zidovir (Zidovudine 300mg Tablets) Side Effects

• Some common side effects of Zidovir (Zidovudine 300mg Tablets) are nausea, headache, vomiting, dizziness, drowsiness, or diarrhea. If any of these effects persist or deteriorate, seek medical attention right away.
• Some people may experience a deteriorating of a previous medical condition as their immune system recovers, or develop new conditions due to overactive immune system. Let your doctor know right away if you develop any new condition or any of you existing conditions worsen.
• Lactic acidosis has been observed in some people who took Zidovir (Zidovudine 300mg Tablets). Initial symptoms of lactic acidosis may deteriorate over time and can prove fatal. Hence you must get medical attention right away on first signs of lactic acidosis such as muscle pain or weakness, numb or cold feeling in the limbs, breathing trouble, stomach pain, or nausea with vomiting.
• Zidovir (Zidovudine 300mg Tablets) can also cause severe or life threatening damage to your liver. Seek medical attention right away if you have any of the following symptoms of liver or pancreas damage: sever pain in upper stomach which advances to the back, nausea and vomiting, fast heartbeats, itching, loss of appetite, dark urine, clay colored stools, or jaundice.
• The side effects mentioned above are not the only ones that you may experience or witness due to Zidovir (Zidovudine 300mg Tablets). If you get any serious side effects due to this medication, contact your doctor right away.

Zidovir (Zidovudine 300mg Tablets) Dosing Information

Zidovir (Zidovudine 300mg Tablets) dosage may depend on a range of factors like age, sex, drug allergies, or seriousness of the condition among several other factors. Your dosage will be determined by your doctor after examining you properly. Remember to follow your doctor’s advice properly for best results.

Zidovir (Zidovudine 100mg Capsule)

Zidovir (Zidovudine 100mg Capsule) contains Zidovudine as an active ingredient. Zidovudine belongs to a class of nucleoside reverse-transcriptase inhibitor (NRTI). It is a blood brain barrier permeable. Zidovudine is an antiretroviral medicine used to treat HIV infection. It is used along with other HIV medications to treat HIV.

What is Zidovir (Zidovudine 100mg Capsule) used for?

Zidovir (Zidovudine 100mg Capsule) is given to patients who suffer from HIV to treat and control their infection, and to reduce the risk of other HIV related illnesses. This drug is a type of nucleoside reverse transcriptase inhibitor, or NRTI, which works by slowing down the spread of HIV in the body. Apart from the above mentioned uses, this drug is also sometimes given to pregnant women with HIV to prevent it being passed to an unborn baby, or to prevent infection in somebody who has come into contact with the virus.

How to Zidovir (Zidovudine 100mg Capsule)  use

Take Zidovir (Zidovudine 100mg Capsule) by mouth 2 to 3 times a day with or with out food as directed by your doctor. Do not miss the dose as drug should be maintained at constant level for better treatment.

How does Zidovir (Zidovudine 100mg Capsule) work?

Zidovir (Zidovudine 100mg Capsule)Zidovir (Zidovudine 100mg Capsule) works by blocking an HIV enzyme called, HIV reverse transcriptase. By doing this, it prevents HIV from replicating and decreases the amount of HIV in the blood.

Working of the drug:

Zidovudine is a nucleoside reverse transcriptase inhibitors (ntris) drug that works by blocking the enzyme called reverse transcriptase. This enzyme is an essential part of replication mechanism of HIV and thus, the drug reduces the amount of infectious virus in the body.

How should Zidovir (Zidovudine 100mg Capsule) be taken?

• Zidovir (Zidovudine 100mg Capsule) comes in the form of a capsule. Taking Zidovir (Zidovudine 100mg Capsule), with a glass of water will help you to swallow it.
• To treat HIV infection in adults: The usual dose of Zidovir (Zidovudine 100mg Capsule) is 600 mg/ day, and it should be taken in divided doses. It is to be taken together with other antiretrovirals agents.
• To treat HIV in pediatrics who aged 4 -<18 years, the dosage regimen is based upon the body weight. Your doctor will prescribe this medicine according to the weight of your child. Alternatively, treatment with Zidovir (Zidovudine 100mg Capsule) may also be based on body surface area for every child. The usual dose is of Zidovudine is 480mg/m2 in divided doses (240 mg/m2 two times a day or 160 mg/m2 three times a day).
• For the prevention of mother-to-child  HIV-1 transmission:

Maternal Dosing- The usual dose of Zidovir (Zidovudine 100mg Capsule) is 100 mg five times a day, until the labor start. During labor and delivery, 2mg/kg of the medicine should be administered intravenously over one hour followed by 1 mg/kg/hour until clamping of the navel string.

Neonatal Dosing: The usual dose of Zidovir (Zidovudine 100mg Capsule) is 2 mg/kg every 6 hours starting within twelve hours after the birth of a child, and the treatment should be continued for 6 weeks of age. In neonates, Zidovir (Zidovudine 100mg Capsule) should be administered intravenously at 1.5 mg/kg, infused over 30 minutes every six hours.

• Do not take more or less amount of capsule than your doctor has prescribed.
• Do not stop taking the capsules without asking your doctor.
• Take the medicine continuously as long as your doctor recommends you. Zidovir (Zidovudine 100mg Capsule) is a drug that prevents further damage caused by the HIV, but it does not cure your condition. You should not stop taking the drug and continue taking it, even if you feel better. Because stopping the intake of the drug may reverse your improving condition.
• Overdose: If you accidently take an extra capsule, call your doctor or hospital casualty department immediately.

Zidovir (Zidovudine 100mg Capsule) Overdose:

If you feel any frightening symptoms, then immediately call the doctor and inform him about the possible side effects of over dosage. If the situation worsens then visit the nearest healthcare center or call the emergency helpline number.

Zidovir (Zidovudine 100mg Capsule) Miss dose:

In case you forget to take the dose, skip the dose and take the next dose on the recommended time period. Do not double up the dose for the missed one.

What are Side effects of Zidovir (Zidovudine 100mg Capsule)?

Like all drugs, Zidovir (Zidovudine 100mg Capsule) can cause side-effects although, not everyone gets them. Contact your doctor, if any of the following symptoms appear:

• Constipation
• Nausea
• Diarrhea
• Blurred vision
• Vomiting
• Constipation
• Headache

Some side effects of Zidovir (Zidovudine 100mg Capsule) can be serious. Call your doctor immediately, if you experience:

• Chills
• Numbness, tingling or burning sensation
• Liver problems
• Skin rashes
• Hives

The side effects that are mentioned above are not the only ones that you may experience due to Zidovir (Zidovudine 100mg Capsule). If you get any serious adverse effects due to Zidovir (Zidovudine 100mg Capsule), call your doctor right away.

What medications interact with Zidovir (Zidovudine 100mg Capsule)?

The following medicines should be avoided, in case doctor recommends you Zidovir (Zidovudine 100mg Capsule) to avoid possible drug interactions.

• Ganciclovir
• Rifampicin
• Doxorubicin
• Sulfa drugs
• Lamivudine
• Sulfa drugs

Duovir-N (Lamivudine 150mg, Zidovudine 300 mg and Nevirapine 200mg Tablets)

Duovir-N (Lamivudine 150mg, Zidovudine 300 mg and Nevirapine 200mg Tablets) contains three drugs: Lamivudine, Nevirapine and Zidovudine. It is the medicine that is used with other HIV drugs for the control of HIV infections. This drug is very effective in decreasing the chances of a person getting infected with this virus. It improves the condition of the patient.

Lamivudine and Zidovudine are both NRTIs i.e. Nucleoside reverse transcriptase inhibitors while Nevirapine is a non-NTRIs(NNTRIs).

Duovir-N (Lamivudine 150mg, Zidovudine 300 mg and Nevirapine 200mg Tablets) is a combination of three drugs commonly used in the management of the human immunodeficiency virus (hiv) infection. Both zidovudine and lamivudine belong to the nucleoside analogue class of antiretroviral drugs. Both drugs act by terminating the growth of the dna chain and inhibiting the reverse transcriptase (rt) of hiv. Nevirapine is a non-nucleoside reverse transcriptase inhibitor (nnrti). It acts by directly inhibiting rt. Each tablet of Duovir-N (Lamivudine 150mg, Zidovudine 300 mg and Nevirapine 200mg Tablets) contains half of the commonly prescribed daily doses of zidovudine, lamivudine and nevirapine. Usually, all three drugs are to be administered twice daily, permitting a fixed-dose combination to be formulated. With the availability of this combination formulation, patients may be better able to adhere to triple drug regimens, thereby enhancing compliance.

Uses of the drug:

This medicine is used for HIV infections. HIV is Human Immunodeficiency Virus; this virus is responsible for spreading AIDS disease. HIV can be transmitted through blood transfusion, mother to child during pregnancy and through sexual contact with infected persons etc.

How does Duovir-N (Lamivudine 150mg, Zidovudine 300 mg and Nevirapine 200mg Tablets) work?

Duovir-N (Lamivudine 150mg, Zidovudine 300 mg and Nevirapine 200mg Tablets) contain a combination of three antiretroviral drugs; nevirapine, zidovudine and lamivudine, which are effective only against RNA viruses (retroviruses) like Human Immunodeficiency Virus (HIV). These three drugs each work by inhibiting the action of the viral-specific enzyme reverse transcriptase (RT) which is needed for the virus to be able to replicate. Retroviruses convert RNA to DNA, which is then integrated into the DNA of infected immune cells so that the virus can replicate. Nevirapine in Duovir-N (Lamivudine 150mg, Zidovudine 300 mg and Nevirapine 200mg Tablets) is a non-nucleoside reverse transcriptase inhibitor (NNRTI); nucleosides are the precursors to the building blocks of DNA and RNA. Nevirapine in Duovir-N (Lamivudine 150mg, Zidovudine 300 mg and Nevirapine 200mg Tablets) acts by binding to a specific site on the RT enzyme, the enzyme's active site known as the NNRTI pocket, disrupting the catalytic site of the enzyme, and blocking its action in a manner that is noncompetitive with nucleosides. Zidovudine and lamivudine are both nucleoside analogue reverse transcriptase inhibitors (NRTI), which means that they block the action of RT by competing with one of the nucleosides needed to transcribe the viral RNA into DNA, becoming incorporated into the chain of newly synthesized viral DNA and preventing it from growing (chain termination). Zidovudine is an analogue of thymidine and lamivudine is an analogue of cytidine. The combined action of the three antiiretroviral drugs in Duovir-N (Lamivudine 150mg, Zidovudine 300 mg and Nevirapine 200mg Tablets) prevents the integration of the virus into the DNA of the infected CD4+ immune cell by 2 different mechanisms, which inhibits the replication of HIV so that no more virus can be produced, and this reduces the viral load (amount of virus). Duovir-N (Lamivudine 150mg, Zidovudine 300 mg and Nevirapine 200mg Tablets) slows down the replication of HIV within your body but does not kill the virus already incorporated in the CD4+ cells or prevent the spread of the infection to others.

Dosage Adjustment

Because Duovir-N (Lamivudine 150mg, Zidovudine 300 mg and Nevirapine 200mg Tablets) is a fixed-dose combination, they should not be prescribed for patients requiring dosage adjustment such as those with reduced renal function (creatinine clearance <50 ml/min), or hepatic impairment, or those experiencing dose-limiting adverse events.

Duovir-N (Lamivudine 150mg, Zidovudine 300 mg and Nevirapine 200mg Tablets) should be discontinued if patients experience severe rash or a rash accompanied by constitutional findings (see warnings and precautions). Patients experiencing mild to moderate rash during the 14-day lead-in period of 200 mg/day should not have their nevirapine dose increased or start therapy with Duovir-N (Lamivudine 150mg, Zidovudine 300 mg and Nevirapine 200mg Tablets) tuntil the rash has resolved (see warnings and precautions). If rash persists beyond the 14-day lead-in period, do not dose escalate to Duovir-N (Lamivudine 150mg, Zidovudine 300 mg and Nevirapine 200mg Tablets) twice daily. The Duovir-N (Lamivudine 150mg, Zidovudine 300 mg and Nevirapine 200mg Tablets) once-daily dosing regimen should not be continued beyond 28 days, after which an alternative regimen should be sought.

If a clinical (symptomatic) hepatic event occurs, nevirapine should be permanently discontinued and not be restarted after recovery .

Patients who interrupt nevirapine dosing for more than 7 days should restart the recommended dosing, using one 200 mg nevirapine tablet daily for the first 14 days (lead-in) in combination with the lamivudine + zidovudine, followed by Duovir-N (Lamivudine 150mg, Zidovudine 300 mg and Nevirapine 200mg Tablets) twice daily in the absence of any signs of hypersensitivity.

Before you take this drug:

Do not take this drug if you:

• Are allergic to this drug or any of the other ingredients of this medicine
• Are pregnant, take all the medicine for HIV prescribed by the doctor, to prevent the spread of HIV to the unborn baby.
• Are breastfeeding or planning to breast feed
• Have very low WBC/ RBC count

Tell your doctor if you:

• Have kidney problems
• Have liver abnormalities
• Have problem related to pancreas
• Have nervous system abnormalities
• Have muscle related problems

Dosage:

How much to take the drug?

Lamivudine dosage may depend on a range of factors like age, sex, drug allergies, or seriousness of the condition among several other factors. Your dosage will be determined by your doctor after examining you properly.

The recommended dose in children/adults having a body weight above 25 kg or more is one tablet twice in a day. Children weighing below 25 kg are not recommended to take the drug.

How to take the drug?

Duovir-N (Lamivudine 150mg, Zidovudine 300 mg and Nevirapine 200mg Tablets) comes as capsule and is taken orally with water. Take this medication with a full glass of water. Follow the directions given by the doctor on your prescription carefully and take is exactly as directed by the doctor. Do not take more or less than the prescription.

Duovir-N (Lamivudine 150mg, Zidovudine 300 mg and Nevirapine 200mg Tablets) can be taken with or without food. Discuss the time of the day the drug should be taken with your doctor and take the capsule as prescribed by him. Take the dose at the correct time and that too the correct quantity because the improvement of the condition of the patient depends upon the correct dose taken at correct time.

For how long to take it?

Continue to take the drug for as long as the doctor recommends. Do not stop taking the medicines without consulting the doctor. Stopping the dose or taking it more often than recommended may cause an increase in the amount of viruses and will make this situation worse and difficult to treat.

Overdose:

Too much Duovir-N (Lamivudine 150mg, Zidovudine 300 mg and Nevirapine 200mg Tablets) or in fact of any other drug is ought to cause some or the other kind of changes in the body. These changes sometimes might be severe and harmful. So, one should never exceed the dose without recommendation from the doctor. In such a case, visit nearest healthcare center or call the emergency helpline number.

Side effects of the drug:

Tell your doctor as soon as possible if you notice any of the following:

• Nausea
• Diarrhea
• Stuffy nose
• Muscle pain
• Unexplained weight loss
• Joint pain
• Vision changes
• Skin rashes, hives and itching
• Tiredness
• Heat intolerance
• Thyroid gland enlargement or goiter
• Increased bruising or bleeding
• Signs of pancreatitis

In above situations you must go for immediate medical help. Do not get alarmed by the list. You may /may not experience all of them. Tell your doctor immediately in the above situations. Discuss with him about the risks and benefits of this treatment.

Common drug interactions:

There are certain drugs that might interfere in the action of the other drugs. Some interactions may result in serious side effects. The following drugs interact with this drug:

• Interferon Alfa
• Probenecid
• Ribavirin
• Stavudine
• Zalcitabine

Some medicines are involved in the removal of Zidovudine such as Fluconazole, Rifampin, and Valproic Acid.

Tell your doctor about all the drugs you have taken in past or are taking including the herbal drugs. Ask your doctor to get the full list of the drugs needed to be avoided while taking the drug as they may interfere it and may cause adverse effects.

Warning:

Things to remember:

• This drug will not keep you from spreading HIV to others so, take the necessary precautions
• The serious effects of this drug mostly occur in women and obese people
• Tell the doctor immediately if the liver problems worsens
• Keep regular contact with your doctor in case of emergency
• Patients should never miss the dose as it’s a part of combination therapy

Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets)

Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) is a combination of lamivudine and zidovudine, which belong to the nucleoside analog class of antiretroviral drugs. Each tablet of Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) contains half of the commonly prescribed daily doses of both lamivudine and zidovudine. With the availability of this combination tablet, patients may be better able to adhere to complex drug treatment regimens, thereby enhancing compliance.

What is Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) used for?

Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) are prescribed to treat HIV infection in patients with or without acquired immunodeficiency syndrome (AIDS). HIV directly affects the immune system by impairing the specific immune cells (CD4) that counter infection, so the risk of life-threatening infection increases. Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) medicine can prevent or slow down the ability of HIV to replicate, lowering the capacity of the virus. This medication functions to increase the number of CD4 cells, providing good strength to the immune system and defying the risk of disease.

How does Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) work?

Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) contain a combination of two antiretroviral drugs lamivudine and zidovudine, which both belong to class of drugs known as nucleoside analogue reverse transcriptase inhibitors (NRTI) that are only effective against retroviruses (RNA virus) like HIV. A nucleoside is a building block of DNA that is needed by the virus to replicate, and nucleoside analogues, like lamivudine and zidovudine in Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets), become incorporated into the DNA that is copied from the virus RNA by an enzyme called reverse transcriptase. This blocks the action of reverse transcriptase and terminates the viral DNA chain so that it cannot become integrated into the DNA of the infected immune cell, which means that no more HIV can be produced. Lamivudine is highly synergistic with zidovudine, which means that it increases the effectiveness of zidovudine so that the combination of these two antiretroviral drugs in Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) slow down the replication of HIV within your body but cannot prevent the spread of the infection to others.

Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) Dosage and Administration

Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) contain 150mg of lamivudine and 300mg of zidovudine. The other variety available, Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) also contains 150mg of lamivudine and 300mg of zidovudine, as well as 200mg of nevirapine. Your physician will decide the required daily dosage and provide you with the necessary details related to the frequency of administration. It is essential that you fully comply with all directions given by your physician. Do not take more than the correct daily dosage, as this could put you at risk of serious health problems.

What does Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) contain?

Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) medicine has a combination of the active ingredients lamivudine (150mg) and zidovudine (300mg). Both of these are antiretroviral drugs that are used to treat HIV infection.

Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) Side effects

Patients undergoing antiretroviral treatment with Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) (Lamivudine/Zidovudine) should be aware that side effects are possible. These may include:

• Headaches
• A blocked nose
• Body fat movement
• Discomfort in the sinuses
• Insomnia or possible fatigue

The above mentioned side effects are usually considered mild, and patients should note that other reactions may also occur. Serious adverse events are generally less common. However, you must get to the hospital or consult a physician immediately if you notice aching of the muscles which does not go away, sores on the skin, soreness in the back that is severe, difficulty walking properly, tremors and any other severe side effects that have not been referenced here.

What medications interact with Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets)?

There is a list of medications that interact with Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) so, they should be avoided along with this drug. Some particular drugs that may react with Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) are anti-infective, pentamidine, amphotericin, flucytosine, vincristine, pyrimethamine, co-trimoxazole, the antiviral ganciclovir, dapsone, vinblastine and doxorubicin for cancer treatment. Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) should not be taken with some other agents like stavudine, emtricitabine, efavirenz, fosamprenavir, indinavir, ketoconazole, itraconazole, and probenecid.

 Some other drugs that are affected by Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) include stavudine, the anticonvulsant phenytoin, and antiretroviral zalicitabine.

When Duovir Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) not be taken?

• One should avoid Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) in the conditions of:
• Allergic to lamivudine or zidovudine or any ingredients in Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets)
• Pregnancy or breastfeeding
• Abnormally low neutrophil counts
• Blood disorders such as anemia or bone marrow problems
• Kidney or liver disease
• Anxiety and sleeping problems
• Immune modulator interferon

How should Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) be taken?

 Usually, you should take Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) as 1 tablet twice daily with a glass of water and with or without food. Your doctor can determine how much and how long this medicine should be taken. If you miss a dose of Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) then take it as soon as you remember, but don’t increase the amount to make up the missed dose.

Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) Precautions

Treatment of HIV with Duovir (Lamivudine 150mg and Zidovudine 300mg Tablets) cannot cure the virus. It will only help your body deal with and fight the infection. Therefore, it is essential that patients are aware of the risk posed to others who they may be in contact with. Take every necessary precaution to ensure that you do not infect anybody else with HIV.

Certain cases in which patients developed a severe and potentially life threatening disorder known as lactic acidosis have been reported. Ask your physician about the symptoms of this condition and get immediate medical help if you believe that you are affected by this condition.